7 Tesla Mr Spectroscopy Reveals That Cd8 T Lymphocyte Depletion Alone Has No Effect on Brain Metabolite Concentrations Confirming the Accelerated Rhesus Macaque Model of Neuroaids
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چکیده
E-M. Ratai, S. Pilkenton, J. Bombardier, C-G. Joo, K. W. Turk, M. R. Lentz, J. He, L. Annamalai, S. O' Neil, S. V. Westmoreland, T. H. Burdo, J. H. Campbell, C. Soulas, P. Autissier, W-K. Kim, K. Williams, and R. G. Gonzalez Radiology, Massachusetts General Hospital A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, Harvard Medical School, Boston, MA, United States, New England Regional Primate Research Center, Southborough, MA, United States, Biology Department, Boston College, Boston, MA, United States, Eastern Virginia Medical School, Norfolk, VA, United States
منابع مشابه
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
Difficulties in understanding the mechanisms of HIV neuropathogenesis include the inability to study dynamic processes of infection, cumulative effects of the virus, and contributing host immune responses. We used H magnetic resonance spectroscopy and studied monocyte activation and progression of CNS neuronal injury in a CD8 lymphocyte depletion model of neuroAIDS in SIV-infected rhesus macaqu...
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OBJECTIVE As ~40% of persons with HIV also suffer neurocognitive decline, we sought to assess metabolic dysfunction in the brains of simian immunodeficiency virus (SIV)-infected rhesus macaques, an advanced animal model, in structures involved in cognitive function. We test the hypothesis that SIV-infection produces proton-magnetic resonance spectroscopic imaging (H-MRSI)-observed decline in th...
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E-M. Ratai, C-G. Joo, J. Bombardier, J. He, L. Annamalai, T. H. Burdo, J. H. Campbell, C. Soulas, P. Autissier, S. V. Westmoreland, K. Williams, and R. G. Gonzalez Radiology, Massachusetts General Hospital A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, New England Regional Primate Research Center, Southborough, MA, United States, Biology Department, Boston College,...
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BACKGROUND Despite the advent of highly active anti-retroviral therapy (HAART), HIV-associated neurocognitive disorders continue to be a significant problem. In efforts to understand and alleviate neurocognitive deficits associated with HIV, we used an accelerated simian immunodeficiency virus (SIV) macaque model of NeuroAIDS to test whether minocycline is neuroprotective against lentiviral-ind...
متن کاملProfound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis
Depletion of CD8(+) lymphocytes during acute simian immunodeficiency virus (SIV) infection of rhesus macaques (RMs) results in irreversible prolongation of peak-level viral replication and rapid disease progression, consistent with a major role for CD8(+) lymphocytes in determining postacute-phase viral replication set points. However, we report that CD8(+) lymphocyte depletion is also associat...
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تاریخ انتشار 2008